Article
Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cells.
European journal of immunology - 1 Mar 2004
Verhasselt Valérie, Vosters Olivier, Beuneu Claire, Nicaise Charles, Stordeur Patrick, Goldman Michel
Abstract excerpt
Current literature suggests that T cells recognizing antigen on mature dendritic cells (DC) differentiate into effector T cells whereas tolerance is induced when antigen is presented by immature DC. We investigated the consequences of the interactions between immature or lipopolysaccharide-matured DC and CD4(pos) T lymphocytes in absence of foreign antigen. While immature DC did not induce significant CD4(pos) T...
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