Article
Dendritic cells in the thymus contribute to T-regulatory cell induction.
Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2008
Proietto Anna I, van Dommelen Serani, Zhou Penghui, Rizzitelli Alexandra, D'Amico Angela, Steptoe Raymond J, Naik Shalin H, Lahoud Mireille H, Liu Yang, Zheng Pan, Shortman Ken, Wu Li
Abstract excerpt
Central tolerance is established through negative selection of self-reactive thymocytes and the induction of T-regulatory cells (T(R)s). The role of thymic dendritic cells (TDCs) in these processes has not been clearly determined. In this study, we demonstrate that in vivo, TDCs not only play a role in negative selection but in the induction of T(R)s. TDCs include two conventional dendritic cell (DC) subtypes,...
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