Article
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2010
Yoda Akinori, Yoda Yuka, Chiaretti Sabina, Bar-Natan Michal, Mani Kartik, Rodig Scott J, West Nathan, Xiao Yun, Brown Jennifer R, Mitsiades Constantine, Sattler Martin, Kutok Jeffrey L, DeAngelo Daniel J, Wadleigh Martha, Piciocchi Alfonso, Dal Cin Paola, Bradner James E, Griffin James D, Anderson Kenneth C, Stone Richard M, Ritz Jerome, Foà Robin, Aster Jon C, Frank David A, Weinstock David M
Abstract excerpt
The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine receptor subunit CRLF2 in a functional screen for B-ALL-derived mRNA transcripts that can substitute for IL3 signaling. We demonstrate that CRLF2 is overexpressed in approximately 15% of adult and high-risk pediatric B-ALL that lack MLL,...
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