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Article

Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemia.

Critical reviews in oncogenesis - 1 Jan 2011

Tasian Sarah K, Loh Mignon L

Abstract excerpt

Recent genomic analyses of childhood and adult B-precursor acute lymphoblastic leukemia (ALL) samples have identified novel genetic alterations in essential lymphoid development and signal transduction pathways, providing insight into the pathogenesis of high-risk ALL associated with treatment failure. Particular advances have been made in unraveling the genetics of ALL associated with overexpression of the...

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Topics

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Share to IKZF1 gene
Share to JAK1 gene
Share to JAK2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

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Identifiers

PMID: 22150304
DOI: 10.1615/critrevoncog.v16.i1-2.30
PMCID: PMC4404310

Genes

CRLF2
IKZF1
JAK1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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The molecular genetic makeup of acute lymphoblastic leukemiaSemantic proximity Read ↗

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