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CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in Oncogenesis

1 Sept 2010

Abstract excerpt

Expression of cytokine receptor-like factor 2 (CRLF2) has recently been shown to be upregulated as well as mutated in populations of B-progenitor acute lymphoblastic leukemia (B-ALL), including Down syndrome (DS-ALL) patients, lacking recurring chromosomal translocations. Increased CRLF2 expression associates with JAK2 mutation, a combination that transforms hematopoietic cells, suggesting that mutant JAK2 and...

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PMID: 20807819
DOI: 10.1158/0008-5472.can-10-1528

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CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in OncogenesisPMID 20807819Read ↗

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