Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia.

Clinical lymphoma, myeloma & leukemia - 1 Jun 2022

Hassan Naglaa M, Abdellateif Mona S, Radwan Enas M, Hameed Sayed Abed, Desouky Eman D El, Kamel Mahmoud M, Gameel Abdallah M

Abstract excerpt

BACKGROUND: The prognostic significance of cytokine receptor-like factor 2 (CRLF2) overexpression in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) is still controversial. We aimed to investigate the role of CRLF2 overexpression and JAK2 mutation in the diagnosis and prognosis of newly diagnosed pediatric B-ALL patients. METHODS: CRLF2 expression was assessed by real-time quantitative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Burkitt Lymphoma
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Prognosis

Share to Receptors, Cytokine

Source

Identifiers

PMID: 34987014
DOI: 10.1016/j.clml.2021.12.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia.PMID 34987014Read ↗

CRLF2-Positive B-Cell Acute Lymphoblastic Leukemia in Adult Patients: A Single-Institution Experience.Semantic proximity Read ↗

Molecular characterization of acute lymphoblastic leukemia with high CRLF2 gene expression in childhoodSemantic proximity Read ↗

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemia.Semantic proximity Read ↗

CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in OncogenesisSemantic proximity Read ↗

[Characteristics and Clinical Significance of CRLF2 Mutations in Adult Acute Lymphoblastic Leukemia].Semantic proximity Read ↗

IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemiaSemantic proximity Read ↗

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.Semantic proximity Read ↗

Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan.Semantic proximity Read ↗

IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Quantitative analysis of IKZF1 gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia: Higher levels are associated with a poorer prognosisSemantic proximity Read ↗

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.