Article
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.
Blood - 1 Jul 2010
Harvey Richard C, Mullighan Charles G, Chen I-Ming, Wharton Walker, Mikhail Fady M, Carroll Andrew J, Kang Huining, Liu Wei, Dobbin Kevin K, Smith Malcolm A, Carroll William L, Devidas Meenakshi, Bowman W Paul, Camitta Bruce M, Reaman Gregory H, Hunger Stephen P, Downing James R, Willman Cheryl L
Abstract excerpt
Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia revealed 29 of 207 cases (14%) with markedly elevated expression of CRLF2 (cytokine receptor-like factor 2). Each of the 29 cases harbored a genomic rearrangement of CRLF2: 18 of 29 (62%) had a translocation of the immunoglobulin heavy chain gene IGH@ on 14q32 to CRLF2 in the pseudoautosomal region...
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