Article
Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions.
Cancer letters - 1 Nov 2017
Sadras Teresa, Heatley Susan L, Kok Chung H, Dang Phuong, Galbraith Kate M, McClure Barbara J, Muskovic Walter, Venn Nicola C, Moore Sarah, Osborn Michael, Revesz Tamas, Moore Andrew S, Hughes Timothy P, Yeung David, Sutton Rosemary, White Deborah L
Abstract excerpt
CRLF2-rearrangements (CRLF2-r) occur frequently in Ph-like B-ALL, a high-risk ALL sub-type characterized by a signaling profile similar to Ph + ALL, however accumulating evidence indicates genetic heterogeneity within CRLF2-r ALL. We performed thorough genomic characterization of 35 CRLF2-r cases (P2RY8-CRLF2 n = 18; IGH-CRLF2 n = 17). Activating JAK2 mutations were present in 34% of patients, and a CRLF2-F232C...
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