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Article

CRLF2-Positive B-Cell Acute Lymphoblastic Leukemia in Adult Patients: A Single-Institution Experience.

American journal of clinical pathology - 1 Apr 2017

Konoplev Sergej, Lu Xinyan, Konopleva Marina, Jain Nitin, Ouyang Juan, Goswami Maitrayee, Roberts Kathryn G, Valentine Marc, Mullighan Charles G, Bueso-Ramos Carlos, Zweidler-McKay Patrick A, Jorgensen Jeffrey L, Wang Sa A

Abstract excerpt

Objectives: Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. We analyzed CRLF2 expression and studied its correlation with CRLF2 rearrangement in adult patients with B-ALL. Methods: Multiparameter flow cytometry (MFC) was performed consecutively in 126...

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Topics

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Share to B-Lymphocytes
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Rearrangement

Share to In Situ Hybridization, Fluorescence

Share to Janus Kinase 2

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, Cytokine

Source

Identifiers

PMID: 28340183
DOI: 10.1093/ajcp/aqx005

Genes

CRLF2
JAK2
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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CRLF2-Positive B-Cell Acute Lymphoblastic Leukemia in Adult Patients: A Single-Institution Experience.PMID 28340183Read ↗

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