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Article

Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute lymphoblastic leukaemia.

British journal of haematology - 1 Feb 2022

Downes Charlotte E J, Rehn Jacqueline, Heatley Susan L, Yeung David, McClure Barbara J, White Deborah L

Abstract excerpt

Rearrangements of Janus kinase 2 (JAK2r) form a subtype of acute lymphoblastic leukaemia (ALL) associated with poor patient outcomes. We present a high-risk case of B-cell ALL (B-ALL) where retrospective mRNA sequencing identified a novel GOLGA4-JAK2 fusion gene. Expression of GOLGA4-JAK2 in murine pro-B cells promoted factor-independent growth, implicating GOLGA4-JAK2 as an oncogenic driver. Cells expressing...

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PMID: 34697799
DOI: 10.1111/bjh.17910

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