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Article

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.

Genes, chromosomes & cancer - 1 May 2017

Russell Lisa J, Jones Lisa, Enshaei Amir, Tonin Stefano, Ryan Sarra L, Eswaran Jeyanthy, Nakjang Sirintra, Papaemmanuil Elli, Tubio Jose M C, Fielding Adele K, Vora Ajay, Campbell Peter J, Moorman Anthony V, Harrison Christine J

Abstract excerpt

Deregulated expression of the type I cytokine receptor, CRLF2, is observed in 5-15% of precursor B-cell acute lymphoblastic leukaemia (B-ALL). We aimed to determine the clinical and genetic landscape of those with IGH-CRLF2 or P2RY8-CRLF2 (CRLF2-r) using multiple genomic approaches. Clinical and demographic features of CRLF2-r patients were characteristic of B-ALL. Patients with IGH-CRLF2 were older (14 y vs. 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28033648
DOI: 10.1002/gcc.22439
PMCID: PMC5396319

Genes

CRLF2
IGH
BTG1
IKZF1
ADD3

Provenance

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