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Article

Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol.

Journal of clinical psychopharmacology - 1 Feb 2008

Kirchheiner Julia, Keulen Jan-Tobias H A, Bauer Steffen, Roots Ivar, Brockmöller Jürgen

Abstract excerpt

The analgesic drug tramadol is bioactivated by CYP2D6 to the opioid receptor agonist O-desmethyltramadol. Case reports indicated that carriers of the CYP2D6 gene duplication may be at high risk for opioid adverse events. However, the effects of the CYP2D6 duplication on kinetics and dynamics of tramadol have not been systematically studied. Pharmacokinetics and effects were monitored after a single dose of 100 mg...

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Source

Identifiers

PMID: 18204346
DOI: 10.1097/JCP.0b013e318160f827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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