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Article

Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.

American journal of respiratory cell and molecular biology - 1 Aug 2011

Nawijn Martijn C, Piavaux Benoit J A, Jeurink Prescilla V, Gras Renée, Reinders Marjan A, Stearns Timothy, Foote Simon, Hylkema Machteld N, Groot Peter C, Korstanje Ron, Oosterhout Antoon J M Van

Abstract excerpt

Mouse models of allergic asthma are characterized by airway hyperreactivity (AHR), Th2-driven eosinophilic airway inflammation, high allergen-specific IgE (anti-OVA IgE) levels in serum, and airway remodeling. Because asthma susceptibility has a strong genetic component, we aimed to identify new asthma susceptibility genes in the mouse by analyzing the asthma phenotypes of the Leishmania major resistant (lmr)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20971879
DOI: 10.1165/rcmb.2009-0369OC
PMCID: PMC3266060

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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