Article
Genetic variability of T cell responses in hypersensitivity pneumonitis identified using the BXD genetic reference panel.
American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2020
Wang Jin, Yoon Tae Won, Read Robert, Yi Ae-Kyung, Williams Robert W, Fitzpatrick Elizabeth A
Abstract excerpt
Hypersensitivity pneumonitis (HP) is an interstitial lung disease that may progress to fibrosis and significant risk of death. HP develops following repeated exposures to inhaled environmental antigens; however, only a fraction of the exposed population develops the disease, suggesting that host genetics contribute to disease susceptibility. We used the BXD family of mice with the Saccharopolyspora rectivirgula...
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