Article
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Nature - 2 Mar 2006
Ramiro Almudena R, Jankovic Mila, Callen Elsa, Difilippantonio Simone, Chen Hua-Tang, McBride Kevin M, Eisenreich Thomas R, Chen Junjie, Dickins Ross A, Lowe Scott W, Nussenzweig Andre, Nussenzweig Michel C
Abstract excerpt
Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies. However, little is known about the molecular mechanism by which primary B cells acquire or guard against these lesions. Here we find that translocations between c-myc and the IgH locus (Igh) are induced in primary B cells within hours of expression of the catalytically active form of...
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