Article
Dynamics of the interaction of human IgG subtype immune complexes with cells expressing R and H allelic forms of a low-affinity Fc gamma receptor CD32A.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2009
Shashidharamurthy Rangaiah, Zhang Fang, Amano Aaron, Kamat Aparna, Panchanathan Ravichandran, Ezekwudo Daniel, Zhu Cheng, Selvaraj Periasamy
Abstract excerpt
CD32A, the major phagocytic FcgammaR in humans, exhibits a polymorphism in the ligand binding domain. Individuals homozygous for the R allelic form of CD32A (CD32A(R) allele) are more susceptible to bacterial infections and autoimmune diseases as compared with H allelic CD32A (CD32A(H)) homozygou...
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