Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.

doi:10.1172/JCI115712

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Article

Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.

The Journal of clinical investigation - 1 Apr 1992

Salmon J E, Edberg J C, Brogle N L, Kimberly R P

Abstract excerpt

Two different allelic polymorphisms among the isoforms of human Fc gamma receptors have been defined: the low-responder (LR)-high-responder (HR) polymorphism of huFc gamma RIIA expressed on both PMN and monocytes and the NA1-NA2 polymorphism of the neutrophil Fc gamma RIII (huFc gamma RIIIB). To...

Topics

Adult
Alleles
Antigens, Differentiation
Homozygote
Humans
Immunoglobulin G
Middle Aged
Neutrophils
Phagocytes
Phagocytosis
Polymorphism, Genetic
Receptors, Fc
Receptors, IgG

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