Article
Flow cytometric determination of FcgammaRIIa (CD32) polymorphism.
Journal of immunological methods - 1 Nov 2004
van Royen-Kerkhof Annet, Sanders Elisabeth A M, Wijngaarden Siska, van Roon Joel A G, Voorhorst-Ogink Marleen, Walraven Vanessa, Gerritsen Arnout, van Dijk Marc A, Kuis W, Rijkers Ger T, Keler Tibor, Leusen Jeanette H W, van de Winkel Jan G J
Abstract excerpt
A guanine to adenine point mutation results in an arginine (R) to histidine (H) substitution in FcgammaRIIa at residue 131 that strongly impacts receptor function. This FcgammaRIIa polymorphism is mostly typed by allele-specific polymerase chain reactions (PCR) or in functional assays, dependent on ligand binding. Both types of methods are laborious, time consuming, and not readily available in routine...
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