Article
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.
Annals of the rheumatic diseases - 1 Dec 2012
Rhodes Benjamin, Fürnrohr Barbara G, Roberts Amy L, Tzircotis George, Schett Georg, Spector Tim D, Vyse Timothy J
Abstract excerpt
OBJECTIVES: The rs1143679 variant of ITGAM, encoding the R77H variant of CD11b (part of complement receptor 3; CR3), is among the strongest genetic susceptibility effects in human systemic lupus erythematosus (SLE). The authors aimed to demonstrate R77H function in ex-vivo human cells. METHODS: Monocytes/monocyte-derived macrophages from healthy volunteers homozygous for either wild type (WT) or 77H CD11b were...
Topics
- Adult
- Animals
- CD11b Antigen
- COS Cells
- Cell Adhesion
- Chlorocebus aethiops
- Cytokines
- Fibroblasts
- Gene Expression
- Genetic Predisposition to Disease
- Genetic Variation