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Evaluation of Human FcγRIIA (CD32) and FcγRIIIB (CD16) Polymorphisms in Caucasians and African-Americans Using Salivary DNA

1 Jul 2000

Abstract excerpt

Two classes of low-affinity receptors for the Fc region of immunoglobulin G (IgG) (FcgammaR) are constitutively expressed on resting human neutrophils. These receptors, termed FcgammaRIIa (CD32) and FcgammaRIIIb (CD16), display biallelic polymorphisms which have functional consequences with respect to binding and/or ingestion of targets opsonized by human IgG subclass antibodies. The H131-R131 polymorphism of...

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PMID: 10882671
DOI: 10.1128/cdli.7.4.676-681.2000

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