Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.

Article

Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.

Blood - 1 Apr 1998

Metes D, Ernst L K, Chambers W H, Sulica A, Herberman R B, Morel P A

Abstract excerpt

Human natural killer (NK) cells were thought to express only FcgammaRIIIA (CD16), but recent reports have indicated that NK cells also express a second type of FcgammaR, ie, FcgammaRII (CD32). We have isolated, cloned, and sequenced full-length cDNAs of FcgammaRII from NK cells derived from sever...

Topics

Alleles
Amino Acid Sequence
Antigens, CD
Gene Expression Regulation
Humans
Killer Cells, Natural
Molecular Sequence Data
Polymorphism, Genetic
Receptors, IgG

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