Article
The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis.
Arthritis and rheumatism - 1 Dec 2006
Radstake Timothy R D J, Franke Barbara, Wenink Mark H, Nabbe Karin C A M, Coenen Marieke J H, Welsing Paco, Bonvini Ezio, Koenig Scott, van den Berg Wim B, Barrera Pilar, van Riel Piet L C M
Abstract excerpt
OBJECTIVE: Fcgamma receptors (FcgammaRs) recognize immune complexes (ICs) and coordinate the immune response by modulating the functions of dendritic cells (DCs). The purpose of this study was to unravel the role of the inhibitory FcgammaRIIb in rheumatoid arthritis (RA) by studying the effect of the FCGR2B 695T>C polymorphism on susceptibility to RA, severity of the disease, and DC function. METHODS: Genotyping...
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