Article
Simple genotyping of functional polymorphisms of the human immunoglobulin G receptors CD16A and CD32A: a reference cell panel.
Tissue antigens - 1 Mar 2008
Vilches C, Castaño J, Muñoz P, Peñalver J
Abstract excerpt
The Fcgamma receptors CD16A and CD32A connect the innate and the adaptive immune responses by transmitting activating signals to natural killer lymphocytes and myeloid cells upon recognition of antigen-immunoglobulin G (IgG) complexes. Two allelic dimorphisms of these receptors, valine/phenylalanine-158 of CD16A and histidine/arginine-131 of CD32A, modulate their affinity for certain human IgG subclasses....
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