Article
Structural analysis of three peptides related to the transmambranic helix VI of AT1 receptor.
Neuropeptides - 1 Apr 2010
de Noronha Samuel Marcos Ribeiro, Corrêa Silvana Aparecida Alves, Poletti Erick Fernando, Lopes Douglas Duarte, da Silva Caroline Corrêa, Sforça Mauricio Luis, Shimuta Suma Imura, Zanchin Nilson Ivo Tonin, Nakaie Clovis Ryuichi, da Silva Ismael Dale Cotrim Guerreiro
Abstract excerpt
INTRODUCTION: Angiotensin II (AII) is the main active product of the renin angiotensin system. Better known effects of AII are via AT1 receptor (AT1R). Expression of AT1R mutants (L265D and L262D) in CHO cells increased cAMP formation when compared to CHO cells expressing the wild type (WT) AT1R....
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