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Article

Aliphatic amino acids in helix VI of the AT(1) receptor play a relevant role in agonist binding and activity.

Regulatory peptides - 15 Jun 2002

Correa Silvana A A, Zalcberg Heloisa, Han Sang W, Oliveira Laerte, Costa-Neto Claudio M, Paiva Antonio C M, Shimuta Suma I

Abstract excerpt

Angiotensin II (AII) AT(1) receptor mutants with replacements of aliphatic amino acids in the distal region of helix VI and the adjoining region of the third extracellular loop (EC-3) were expressed in Chinese hamster ovary (CHO) cells to determine their role in ligand binding and activation. The triple mutant [L262D, L265D, L268D]AT(1) (L3D) showed a marked reduction in affinity for AII and for non-peptide...

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PMID: 12047908
DOI: 10.1016/s0167-0115(02)00033-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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