Article
Mutations in transmembrane segment VII of the AT1 receptor differentiate between closely related insurmountable and competitive angiotensin antagonists.
British journal of pharmacology - 1 Oct 1994
Schambye H T, von Wijk B, Hjorth S A, Wienen W, Entzeroth M, Bergsma D J, Schwartz T W
Abstract excerpt
Chimeric constructs between the human and the Xenopus laevis AT1 receptor have demonstrated, that the binding of non-peptide angiotensin antagonists is dependent on non-conserved residues located deep in transmembrane segment VII of the AT1 receptor. Here we have studied four pairs of closely related antagonists each consisting of a competitive and an insurmountable compound differentiated by one out of three...
Topics
- Amino Acid Sequence
- Angiotensin I
- Angiotensin Receptor Antagonists
- Animals
- Binding, Competitive
- Humans
- In Vitro Techniques
- Ligands
- Membranes
- Molecular Sequence Data