Article
The human VPAC1 receptor: three-dimensional model and mutagenesis of the N-terminal domain.
The Journal of biological chemistry - 30 Mar 2001
Lins L, Couvineau A, Rouyer-Fessard C, Nicole P, Maoret J J, Benhamed M, Brasseur R, Thomas A, Laburthe M
Abstract excerpt
The human VPAC(1) receptor for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide belongs to the class II family of G-protein-coupled receptors with seven transmembrane segments. Like for all class II receptors, the extracellular N-terminal domain of the human VPAC(1) receptor plays a predominant role in peptide ligand recognition. To determine the three-dimensional structure...
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