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Article

Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.

The Journal of biological chemistry - 19 Aug 1994

Marie J, Maigret B, Joseph M P, Larguier R, Nouet S, Lombard C, Bonnafous J C

Abstract excerpt

An essential role of the conserved Asp74 in the coupling of the type 1 angiotensin II (AII) receptor (AT1) to phospholipase C has already been reported (Bihoreau, C., Monnot, C., Davies, E., Teutsch, B., Bernstein, K. B., Corvol, P., and Clauser, E. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5133-5137). Moreover, preliminary modeling studies have shown that a spatial proximity exists between Asp74, located in...

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PMID: 8063694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.PMID 8063694Read ↗

Relationship between ligand binding and YIPP motif in the C-terminal region of human AT1 receptor.Semantic proximity Read ↗

Aliphatic amino acids in helix VI of the AT(1) receptor play a relevant role in agonist binding and activity.Semantic proximity Read ↗

Role of Lys215 located in the fifth transmembrane domain of the AT2 receptor in ligand-receptor interaction.Semantic proximity Read ↗

Identification of structural determinants for G protein-independent activation of mitogen-activated protein kinases in the seventh transmembrane domain of the angiotensin II type 1 receptor.Semantic proximity Read ↗

Participation of transmembrane proline 82 in angiotensin II AT1 receptor signal transduction.Semantic proximity Read ↗

Several interesting phenotypes of the AT1 receptor produced by site-directed mutagenesis.Semantic proximity Read ↗

Mutation of peptide binding site in transmembrane region of a G protein-coupled receptor accounts for endothelin receptor subtype selectivity.Semantic proximity Read ↗

Lys(199) mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists.Semantic proximity Read ↗

Mutations in transmembrane segment VII of the AT1 receptor differentiate between closely related insurmountable and competitive angiotensin antagonists.Semantic proximity Read ↗

Identification of the region of AT2 receptor needed for inhibition of the AT1 receptor-mediated inositol 1,4,5-triphosphate generation.Semantic proximity Read ↗

Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.Semantic proximity Read ↗

Single mutations at Asn295 and Leu305 in the cytoplasmic half of transmembrane alpha-helix domain 7 of the AT1 receptor induce promiscuous agonist specificity for angiotensin II fragments: a pseudo-constitutive activity.Semantic proximity Read ↗

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