Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.

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Article

Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.

The Journal of biological chemistry - 19 Aug 1994

Marie J, Maigret B, Joseph M P, Larguier R, Nouet S, Lombard C, Bonnafous J C

Abstract excerpt

An essential role of the conserved Asp74 in the coupling of the type 1 angiotensin II (AII) receptor (AT1) to phospholipase C has already been reported (Bihoreau, C., Monnot, C., Davies, E., Teutsch, B., Bernstein, K. B., Corvol, P., and Clauser, E. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5133...

Topics

Animals
CHO Cells
Cell Membrane
Computer Graphics
Cricetinae
Cricetulus
GTP-Binding Proteins
Mutation
Protein Conformation
Rats
Receptors, Angiotensin
Type C Phospholipases
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 8063694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8063694-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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