Article
A role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin II AT1 receptor.
Biological chemistry - 1 Mar 2006
Pignatari Graciela C, Rozenfeld Raphael, Ferro Emer S, Oliveira Laerte, Paiva Antonio C M, Devi Lakshmi A
Abstract excerpt
Several studies have proposed that angiotensin II (Ang II) binds to its receptor AT1 through interactions with residues in helices V and VI, suggesting that the distance between these helices is crucial for ligand binding. Based on a 3D model of AT1 in which the C-terminus of Ang II is docked, we identified the hydrophobic residues of TM V and VI pointing towards the external face of the helices, which may play a...
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