Article
3D model for TM region of the AT-1 receptor in complex with angiotensin II independently validated by site-directed mutagenesis data.
Biochemical and biophysical research communications - 7 Sept 2001
Nikiforovich G V, Marshall G R
Abstract excerpt
A three-dimensional model of the complex of angiotensin II (AII) with the transmembrane (TM) region of the angiotensin II receptor of type 1 (the AT-1 receptor) was obtained by molecular modeling procedures employing structural homology to the X-ray structure of rhodopsin. Since the modeling procedure considered only steric and energy considerations without prior knowledge of the experimental results of...
Topics
- Amino Acid Sequence
- Crystallography, X-Ray
- Histidine
- Ligands
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Phenylalanine
- Protein Binding
- Protein Conformation
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Receptors, Angiotensin
- Rhodopsin
- Signal Transduction