Article
3D model for TM region of the AT-1 receptor in complex with angiotensin II independently validated by site-directed mutagenesis data.
Biochemical and biophysical research communications - 7 Sept 2001
Nikiforovich G V, Marshall G R
Abstract excerpt
A three-dimensional model of the complex of angiotensin II (AII) with the transmembrane (TM) region of the angiotensin II receptor of type 1 (the AT-1 receptor) was obtained by molecular modeling procedures employing structural homology to the X-ray structure of rhodopsin. Since the modeling procedure considered only steric and energy considerations without prior knowledge of the experimental results of...
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