Article
Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice.
Neuropathology and applied neurobiology - 1 Jun 2010
Ryu K-Y, Fujiki N, Kazantzis M, Garza J C, Bouley D M, Stahl A, Lu X-Y, Nishino S, Kopito R R
Abstract excerpt
AIMS: Ubiquitin performs essential roles in a myriad of signalling pathways required for cellular function and survival. Recently, we reported that disruption of the stress-inducible ubiquitin-encoding gene Ubb reduces ubiquitin content in the hypothalamus and leads to adult-onset obesity coupled...
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