Article
Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice.
Endocrinology - 1 Aug 2014
Ignacio-Souza Leticia M, Bombassaro Bruna, Pascoal Livia B, Portovedo Mariana A, Razolli Daniela S, Coope Andressa, Victorio Sheila C, de Moura Rodrigo F, Nascimento Lucas F, Arruda Ana P, Anhe Gabriel F, Milanski Marciane, Velloso Licio A
Abstract excerpt
In both human and experimental obesity, inflammatory damage to the hypothalamus plays an important role in the loss of the coordinated control of food intake and energy expenditure. Upon prolonged maintenance of increased body mass, the brain changes the defended set point of adiposity, and returning to normal weight becomes extremely difficult. Here we show that in prolonged but not in short-term obesity, the...
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