Article

IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington’s disease mouse model

2021-04-09

Abstract excerpt

<h4>Background</h4> Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin ( HTT ) gene. Metabolic changes are associated with HD progression, and underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an essential regulator of metabolism, we investigated the involvement of IKKβ, the upstream activator of NF-κB in hypothalamus-specific HD met...

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Literature Corpus work: e3561b06-dc99-58b1-9a54-60ba103debaa
DOI: 10.1101/2021.04.08.438894

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