Article

Altered circadian rhythms and sleep in a new Angelman Syndrome mouse model

2021-10-28

Abstract excerpt

Normal neurodevelopment requires precise expression of the key ubiquitin ligase gene Ube3a . Comparing newly generated mouse models for Ube3a down-regulation (models of Angelman syndrome) vs. Ube3a up-regulation (models for autism), we find reciprocal effects of Ube3a gene dosage on phenotypes associated with circadian rhythmicity, including the amount of locomotor activity. In contrast to previous reports, we...

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Literature Corpus work: d1d3851c-3205-5ea1-9d1c-2d179e7ad722
DOI: 10.1101/2021.10.26.465956

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