Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice.

Physiology & behavior - 1 Nov 2002

Coyle Christopher A, Jing Enxuan, Hosmer Trina, Powers J Bradley, Wade George, Good Deborah J

Abstract excerpt

Targeted deletion of the neuronal basic helix-loop-helix transcription factor Nhlh2 results in adult-onset obesity in mice. Measurement of body weight and body composition in animals aged 3-25 weeks indicates that while male and female Nhlh2 knockout (N2KO) animals both show adult-onset obesity, the time frame for development of obesity is different, with females becoming obese by 7 weeks of age and males...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Composition
Share to Body Temperature
Share to Eating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Motor Activity

Share to Physical Exertion

Share to Postural Balance

Share to Thermogenesis

Source

Identifiers

PMID: 12419415
DOI: 10.1016/s0031-9384(02)00885-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice.PMID 12419415Read ↗

Nhlh2Semantic proximity Read ↗

Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans.Semantic proximity Read ↗

Inactivating NHLH2 Variants Cause Idiopathic Hypogonadotropic Hypogonadism and Obesity in HumansSemantic proximity Read ↗

Orexin-A/hypocretin-1 Immunoreactivity in the Lateral Hypothalamus is Reduced in Genetically Obese but not in Diet-induced Obese Mice.Semantic proximity Read ↗

High fat diet rescues disturbances to metabolic homeostasis and survival in the Id2 null mouse in a sex-specific manner.Semantic proximity Read ↗

Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.Semantic proximity Read ↗

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.Semantic proximity Read ↗

Mice lacking dopamine production in neurotensin receptor 1 neurons voluntarily undergo time-restricted feeding of high fat diet and resist obesitySemantic proximity Read ↗

Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice.Semantic proximity Read ↗

Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice.Semantic proximity Read ↗

Mice with altered brain lipoprotein metabolism display maladaptive responses to environmental challenges that may predispose to weight gain.Semantic proximity Read ↗

Energy expenditure deficits drive obesity in a mouse model of Alström syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.