Article

A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice

2025-12-09

Abstract excerpt

Mammalian circadian organisation is orchestrated by a light entrained master pacemaker in the suprachiasmatic nucleus (SCN) and SCN independent, food and metabolism responsive oscillators in the brain and periphery; feeding can entrain these systems, enabling anticipation of feeding time. Here, we show that a human missense variant (Q159K) in the homeodomain of the brain specific transcription factor BSX causes pr...

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Literature Corpus work: fb8e929d-6883-57a7-af69-09718e6b2cd7
DOI: 10.64898/2025.12.05.692520

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