Article
Development of an allele-specific PCR for detection of the K65R resistance mutation in patients infected with subtype C human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy - 1 Feb 2010
Toni Thomas A, Brenner Bluma G, Asahchop Eugene L, Ntemgwa Michel, Moisi Daniella, Wainberg Mark A
Abstract excerpt
The selection of drug-resistant variants of human immunodeficiency virus type 1 (HIV-1) is an impediment to the efficiency of antiretroviral (ARV) therapy. We have developed an allele-specific real-time PCR assay to explore the presence of K65R minority species among treated HIV-1 subtype B and C infections. Thirty HIV-1 subtype C- and 26 subtype B-infected patients lacking K65R as determined by conventional...
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