Article
Detection and quantification of minority HIV isolates harbouring the D30N mutation by real-time PCR amplification.
The Journal of antimicrobial chemotherapy - 1 Oct 2007
Detsika Maria G, Chandler Becky, Khoo Saye H, Winstanley Craig, Cane Pat, Back David J, Owen Andrew
Abstract excerpt
OBJECTIVES: HIV drug resistance is a major concern as the emergence of resistant strains of virus results in failure of first-line therapies with an associated increase in the cost of subsequent regimens. Genotypic resistance is currently assessed by direct sequencing and cannot detect resistant species below 20%. Real-time PCR amplification was assessed for its ability to detect the signature mutation for...
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