Article
Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naïve patients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Feb 2011
Metzner Karin J, Rauch Pia, Braun Patrick, Knechten Heribert, Ehret Robert, Korn Klaus, Kaiser Rolf, Sichtig Nadine, Ranneberg Britta, van Lunzen Jan, Walter Hauke
Abstract excerpt
BACKGROUND AND OBJECTIVES: Minority drug-resistant HIV-1 variants, undetected by conventional genotyping, may impair the outcome of antiretroviral therapy (ART). Thus, we retrospectively analyzed the prevalence of minority drug-resistant HIV-1 variants before ART in chronically HIV-1 infected patients initiating first-line therapy and assessed the impact on clinical outcome in the prospective German Truvada...
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