Article
Detection of low-level K65R variants in nucleoside reverse transcriptase inhibitor-naive chronic and acute HIV-1 subtype C infections.
The Journal of infectious diseases - 15 Mar 2011
Li Jin-fen, Lipscomb Jonathan T, Wei Xierong, Martinson Neil A, Morris Lynn, Heneine Walid, Johnson Jeffrey A
Abstract excerpt
To substantiate reports of greater emergence of the K65R nucleoside reverse transcriptase inhibitor (NRTI) mutation in human immunodeficiency virus type 1 (HIV-1) subtype C, we examined natural low-level K65R expression in subtype C relative to subtypes B and AE. We used allele-specific polymerase chain reaction to screen HIV-1 amplified by reverse-transcription high-fidelity polymerase chain reaction from...
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