Article
Isolation of a mutant of Chinese hamster ovary cells with defective secretion of a subset of secretory proteins.
Somatic cell and molecular genetics - 1 Jan 1991
Kaiden A, Krag S S
Abstract excerpt
The secretory pathway of mammalian cells involves a complex sequence of steps beginning with the translation and translocation of proteins across the rough endoplasmic reticulum membrane followed by their transport through a variety of intracellular compartments. Understanding the cellular mechanisms involved in protein transport would be facilitated by the application of somatic cell genetics techniques....
Topics
- Animals
- Cell Line
- Cricetinae
- Cricetulus
- Cycloheximide
- Fibronectins
- In Vitro Techniques
- Mannose
- Molecular Weight
- Mutation
- Proteins
- Secretory Rate