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Article

Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate.

The Journal of biological chemistry - 24 Apr 2009

Cattaneo Monica, Lotti Lavinia Vittoria, Martino Simone, Cardano Marina, Orlandi Rosaria, Mariani-Costantini Renato, Biunno Ida

Abstract excerpt

SEL1L-A, a transmembrane glycoprotein residing in the endoplasmic reticulum (ER), is a component of the ER-associated degradation (ERAD) pathway. Alternative splicing generates two smaller SEL1L isoforms, -B and -C, that lack the SEL1L-A membrane-spanning region but retain some sel-1-like repeats, known to be involved in multi-protein interactions and signal transduction. In this study the functional...

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Identifiers

PMID: 19204006
DOI: 10.1074/jbc.M805408200
PMCID: PMC2670146

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