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The secretory pathway – the key for unlocking the potential of Chinese hamster ovary cell factories for manufacturing therapeutic proteins

24 Apr 2022

Abstract excerpt

Mammalian cell factories (in particular the CHO cell system) have been crucial in the rise of biopharmaceuticals. Mammalian cells have compartmentalized organelles where intricate networks of proteins manufacture highly sophisticated biopharmaceuticals in a specialized production pipeline - the secretory pathway. In the bioproduction context, the secretory pathway functioning is key for the effectiveness of cell...

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PMID: 35465810
DOI: 10.1080/07388551.2022.2047004

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