Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development.

doi:10.1242/jcs.112.23.4389

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Article

Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development.

Journal of cell science - 1 Dec 1999

Valcárcel R, Weber U, Jackson D B, Benes V, Ansorge W, Bohmann D, Mlodzik M

Abstract excerpt

We have identified and isolated mutations in the first Drosophila gene encoding a subunit of the Sec61 protein translocation channel, DSec61beta. While neither the Saccharomyces cerevisiae Sec61beta nor its functional Escherichia coli homologue are essential for viability or for protein translocation, we show that DSec61beta is essential for embryonic development. Homozygous mutant embryos die at the end of...

Topics

Alleles
Amino Acid Sequence
Animals
Body Patterning
Chorion
Dogs
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
Escherichia coli
Female
Humans
Ion Channels
Membrane Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Molecular Sequence Data

Oocytes

SEC Translocation Channels

Source

Open in PubMed

Identifiers

PMID: 10564656
DOI: 10.1242/jcs.112.23.4389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.