Article
Lunatic fringe promotes the lateral inhibition of neurogenesis.
Development (Cambridge, England) - 1 Aug 2009
Nikolaou Nikolas, Watanabe-Asaka Tomomi, Gerety Sebastian, Distel Martin, Köster Reinhard W, Wilkinson David G
Abstract excerpt
Previous studies have identified roles of the modulation of Notch activation by Fringe homologues in boundary formation and in regulating the differentiation of vertebrate thymocytes and Drosophila glial cells. We have investigated the role of Lunatic fringe (Lfng) expression during neurogenesis in the vertebrate neural tube. We find that in the zebrafish hindbrain, Lfng is expressed by progenitors in neurogenic...
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