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Article

BAX activation is initiated at a novel interaction site.

Nature - 23 Oct 2008

Gavathiotis Evripidis, Suzuki Motoshi, Davis Marguerite L, Pitter Kenneth, Bird Gregory H, Katz Samuel G, Tu Ho-Chou, Kim Hyungjin, Cheng Emily H-Y, Tjandra Nico, Walensky Loren D

Abstract excerpt

BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such as BCL-2 counteract BAX-mediated cell death. Although an interaction site that confers survival functionality has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18948948
DOI: 10.1038/nature07396
PMCID: PMC2597110

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18948948-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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