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Article

Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.

The Journal of biological chemistry - 8 Mar 2013

Ha Ji-Hyang, Shin Jae-Sun, Yoon Mi-Kyung, Lee Min-Sung, He Fahu, Bae Kwang-Hee, Yoon Ho Sup, Lee Chong-Kil, Park Sung Goo, Muto Yutaka, Chi Seung-Wook

Abstract excerpt

Molecular interactions between the tumor suppressor p53 and the anti-apoptotic Bcl-2 family proteins play an important role in the transcription-independent apoptosis of p53. The p53 transactivation domain (p53TAD) contains two conserved ΦXXΦΦ motifs (Φ indicates a bulky hydrophobic residue and X is any other residue) referred to as p53TAD1 (residues 15-29) and p53TAD2 (residues 39-57). We previously showed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23316052
DOI: 10.1074/jbc.M112.400754
PMCID: PMC3591646

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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