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Article

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.

Cell cycle (Georgetown, Tex.) - 1 Oct 2012

Liu Qian, Leber Brian, Andrews David W

Abstract excerpt

Increased interactions between pro-apoptotic BH3-only proteins and anti-apoptotic Bcl-2 family proteins at mitochondria result in tumor initiation, progression and resistance to traditional chemotherapy. Drugs that mimic the BH3 region are expected to release BH3-only proteins from anti-apoptotic proteins, inducing apoptosis in some cancer cells and sensitizing others to chemotherapy. Recently, we applied...

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Identifiers

PMID: 22895112
DOI: 10.4161/cc.21462
PMCID: PMC3478303

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