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Article

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

The Journal of biological chemistry - 31 Mar 2006

Tomita York, Marchenko Natasha, Erster Susan, Nemajerova Alice, Dehner Alexander, Klein Christian, Pan Hongguang, Kessler Horst, Pancoska Petr, Moll Ute M

Abstract excerpt

The induction of apoptosis by p53 in response to cellular stress is its most conserved function and crucial for p53 tumor suppression. We recently reported that p53 directly induces oligomerization of the BH1,2,3 effector protein Bak, leading to outer mitochondrial membrane permeabilization (OMMP...

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PMID: 16443602
DOI: 10.1074/jbc.M507611200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16443602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.PMID 16443602Read ↗

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