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Article

Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport.

Scientific reports - 29 May 2015

Rajan Sreekanth, Choi Minjoo, Nguyen Quoc Toan, Ye Hong, Liu Wei, Toh Hui Ting, Kang CongBao, Kamariah Neelagandan, Li Chi, Huang Huiya, White Carl, Baek Kwanghee, Grüber Gerhard, Yoon Ho Sup

Abstract excerpt

Bcl-2 family proteins are key regulators for cellular homeostasis in response to apoptotic stimuli. Bcl-xL, an antiapoptotic Bcl-2 family member, undergoes conformational transitions, which leads to two conformational states: the cytoplasmic and membrane-bound. Here we present the crystal and small-angle X-ray scattering (SAXS) structures of Bcl-xL treated with the mild detergent n-Octyl β-D-Maltoside (OM). The...

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Identifiers

PMID: 26023881
DOI: 10.1038/srep10609
PMCID: PMC4448555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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